Scientists have discovered how the immune system helps to kill germs in the body

© Illustration RIA Novosti . Alina Planinata the artist imagined as streptococci «preprogramming» immunityScientists have discovered how the immune system helps to kill germs in the body© Illustration RIA Novosti . Alina Polyanina

Blood poisoning leads to rapid destruction of your body and to the massive violations in its work due to the fact that some bacteria are able to «reprogram» immune cells and cause them to attack the tissues of the body, according to an article published in the journal PLoS Biology.

«We found that so-called MAIT-cells do not help fight infection, but rather are its accomplices. They are the main source of interferon-gamma, signaling molecules associated with inflammation and is one of the main causes of death. Accordingly, the suppression of these cells may help people avoid the development of inflammation and death,» says Mansur Cherifer (Mansour Haeryfar) from Western University in London (Canada).

Blood poisoning, as the scientists explain, arises from the fact that immune cells are massively dying from the toxins contained in the shell of the germs, which penetrated into the bloodstream. Once in the blood and immune cells, these substances cause an inflammatory reaction and saturate the chemically aggressive molecules. As a result, the entire blood and immune system is disturbed, and in some organs the blood ceases to flow at all.

The human body and other animals trying to defend themselves against such an outcome, producing a set of anti-inflammatory proteins that help cells to maintain their livelihoods under stressful conditions. They help not always, and in about half the cases a person is not experiencing similar violations perish and.

Such «dispersion of attention» of the immune system leads to several consequences, which is very important for microbes, including what the immune system actually begins to destroy your body and rapidly depleted. When the inflammatory reaction is over, the MAIT-cells are almost completely cease to pay attention to microbes, which further simplifies their lives and opens the way for secondary infections.

Accordingly, the blocking or suppression of the work of MAIT-cells in the development of blood poisoning can save a life and help him avoid the weakening of the immune system after an exit from the crisis. Now scientists are working to develop antibodies that could temporarily «disable» MAIT-cells at the onset of sepsis.

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