Scientists have discovered bacteria in the brains of people with Alzheimer’s disease

© Fotolia / ktsdesignСтроение neuron of the brainScientists have discovered bacteria in the brains of people with Alzheimer’s disease© Fotolia / ktsdesign

Biologists have discovered an unknown microbes in the brain of people suffering from Alzheimer’s, which once again pointed to the potentially infectious nature of the disease, according to a paper published in the journal Frontiers in Aging Neuroscience.

«The brains of people with Alzheimer’s usually has traces of inflammation, and we more and more think about the fact that these inflammations can cause death of nerve cells and further development of the disease. It is possible that this inflammation is a reaction to the emergence of germs inside the brain,» says David emery (David Emery) from the University of Bristol (UK).

In September 2015, the researchers from the UK found from studying the brains of people who died from mad cow disease, what Alzheimer’s disease actually can be transmitted from one person to another through as a result of «contamination» of their nervous tissue to foreign prions.

Prions represent «balls» matted and incorrectly assembled protein molecules that accumulate in the nerve cells of sick people, and as it turns out, can boost the appearance of plaques of beta-amyloid in the neurons of healthy people in contact with their blood and brain.

This first set of physicians to the fact that Alzheimer’s might be contagious. A carrier and a source of prions, as scientists have discovered already this year, there may be some bacteria that is able to penetrate the brain of animals. In addition, biologists have found that prions can be part of the immune system, protecting the cells from germs and other pathogens.

Emery and his colleagues found unexpected evidence that in the brain of these people do have microbes, studying the contents of the nerve tissue of several healthy individuals who died of natural causes, and victims of Alzheimer’s disease.

Analyzing strands of DNA extracted from these samples, scientists discovered that fragments of genes of microbes present in healthy and diseased brain, but in the latter they were approximately seven times more, and the number of some bacteria such as Actinobacteria was higher in the brain of sick people dozens of times.

While biologists believe that this is due to the fact that the barrier between the brain and the circulatory system may, over time, become more permeable for germs living in the blood. Penetrating the brain, they trigger inflammation, cause prions to accumulate within neurons and lead to their mass destruction.

Now scientists are conducting detailed genetic analyses of these microbes in an attempt to understand how they could get into the brain of patients and whether inflammation caused by them, are the cause of development of Alzheimer’s disease.


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