Russian scientists are on the verge of creating new drugs for stroke

© Fotolia / romasetМедицинская laboratoryRussian scientists are on the verge of creating new drugs for stroke© Fotolia / romaset

Scientists from southern Federal University, found in the rat brain, a number of proteins that might serve as new targets for developing drugs that protect nerve cells and limit brain damage after a stroke. The research was carried out in the framework of the project supported by a grant from the Russian science Foundation (RNF). The results were published in the journal Molecular Neurobiology.

Stroke is the third cause of mortality and the first cause of disability in the population. Ischemic stroke is when a blood clot clogs the blood vessels of the brain, stops the supply of nerve cells with oxygen and glucose. It for a few minutes leads to local infarction — necrosis of the nervous tissue. In such a short time is impossible to save the nerve cells in the necrotic foci.

Scientists from different countries have already experienced more than a thousand substances that demonstrated positive results in experiments on animals, and spent more than two hundred clinical trials, but have not yet found any of the neuroprotective drug with proved effectiveness to protect the human brain from ischemic injury without causing harmful side effects.

For a better understanding of the mechanisms of stroke, the researchers used experimental model — fotochromatyczne stroke, which by means of laser irradiation in the cerebral cortex of a rat or mouse creates a local blockage of blood vessels.

The authors note that further it is necessary to study intracellular signaling pathways and transcription factors that control the synthesis of proteins responsible for the death of brain cells in the development of stroke. The second task is to find activators or inhibitors of such proteins and regulator proteins that could be potential neuroprotective agents.

«The price issue is huge, we are talking about developing new approaches to treatment strategies of stroke, new drugs, allowing in the end to reduce mortality and disability of people», — concluded Anatoly uzdensky.