Russian scientists have found a new way to treat traumatic brain injury

© Fotolia / Sergey NivensВрач studying pictures of the human brainRussian scientists have found a new way to treat traumatic brain injury© Fotolia / Sergey use Nivens

Employees of the Institute of physico-chemical biology named after A. N. Belozersky and faculty of bioengineering and bioinformatics of MSU named after M. V. Lomonosov have found that the introduction of vitamin B1 to the patient with traumatic brain injury helps to restore the brain functions. The results of the study accepted for publication in the journal Shock.Acute traumatic brain injury (TBI) is one of the main causes of disability among the working population. TBI leads to physical, psychological and cognitive damage, disrupts the function of mitochondria — organelles of the cell responsible for the oxidation of organic compounds and use the released in their decay energy for different processes in the body. While scientists have not yet described the mechanisms responsible for mitochondrial function to the extent which would allow to offer an effective therapeutic strategy for the treatment of patients with traumatic brain injury.

CC BY-SA 2.0 / Rehman T, Ali R, Tawil I, Yonas H / STKT Brain trauma patients with brain injuryRussian scientists have found a new way to treat traumatic brain injuryCC BY-SA 2.0 / Rehman T, Ali R, Tawil I, Yonas H / STKT Brain trauma patients with brain injury

«In this work, we first showed that in mitochondria of the cerebral cortex traumatic brain injury causes dysfunction of the mitochondrial multienzyme complex 2-oxoglutarate dehydrogenase (complex molecules that speed up chemical reactions in living organisms). Moreover, we have prevented such a dysfunction in TBI introduction vitamin B1 (thiamine), which is the physiological activator of this complex. Obtained in an animal model results indicate that injection of high doses of thiamine to patients with traumatic lesions of the CNS may have beneficial effects for restoring brain function,» explained the authors of the article, a leading researcher of the Department of biokinetics, Institute FHB Moscow state University, doctor of chemical Sciences, Victoria Bunik and PhD student of faculty of bioengineering and bioinformatics, Moscow state University, Garik Mkrtchyan.

CC BY 2.5 / Patrick J. Lynch, medical illustrator / ContrecoupУшиб from shock and protivocorRussian scientists have found a new way to treat traumatic brain injuryCC BY 2.5 / Patrick J. Lynch, medical illustrator / ContrecoupУшиб from shock and protivocor

The researchers performed the work using the animal model of TBI. They examined mitochondrial function by the methods of medical Enzymology. For many years, the authors develop the idea of the leading role of the enzyme 2-oxoglutarate dehydrogenase in brain pathologies. Scientists have proposed a number of regulators of this enzyme, which can be used for correction of pathological conditions.

«Since thiamine is a well-known pharmacological drug can be recommended its introduction in traumatic brain injury as a neuroprotectant substance, warning of the damage to brain cells,» the scientists concluded.

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