Scientists found in the intestine the enzyme influencing the duration of life

© RIA Novosti / Alexander Krauledat in fotoreceptori. Archival photoScientists found in the intestine the enzyme influencing the duration of life© RIA Novosti / Alexander Krajevima the image Bank

Scientists from the UK and the Netherlands were able to increase the lifespan of flies and worms by limiting the activity of the enzyme, common to all living beings, including humans, writes Eurekalert!.

The reduced activity of the Pol III enzyme in the gut of flies and worms was sufficient to extend their life. Also flies lived longer when the activity of the enzyme was suppressed only in stem cells of their intestines.

The enzyme RNA polymerase III (Pol III), which was subjected to inhibition, is necessary for protein synthesis and for cell growth. However, as the newspaper notes, its role in aging has not been studied so far.

According to the researchers, the survival ability of cells of yeast and the duration of life of flies and worms increased by 10% on average with a small decrease in Pol III activity in an adult organism.

In their study, the researchers used a variety of methods genetics including mutagenesis by the method of injection and RNA interference, to inhibit this enzyme, then, an increase in life expectancy. For tests used yeast, flies and worms, since these organisms differ from each other, but all have Pol III.

Now the researchers plan to deepen the knowledge about the enzyme, to understand its function in the adult organism, and shed light on how a reduction of its activity may extend life.

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