Russian scientists had «grown» a bony shell on the titanium implants

© Photo : press service of Trasperant Engineering school of nuclear technology TPU Roman black earthRussian scientists had «grown» a bony shell on the titanium implants© Photo : press service of the TPU

Scientists in the Engineering school of nuclear technology and Engineering school of new production technologies of Tomsk Polytechnic University (participant of the Federal program «5-100»), together with leading experts in the field of medical materials science from the University of Duisburg (Germany), Karlsruhe Institute of Technology (Germany) and the University of California riverside (USA) have developed a method for the synthesis of nanotubes of titanium dioxide with the application of calcium-phosphate coatings that are identical in composition to human bone. Due to such coatings can improve the survival rate of titanium bone implants and to provide a new channel for access to medicines.

As the authors development, titanium is widely used today for the manufacture of implants, but it is much harder than bone due to the different values of elasticity. When the patient moves the Titan takes on more mechanical loads than the bones that can lead to the destruction of bone tissue.

«Nanotubes allow you to solve the problem – says the graduate of the Engineering school of nuclear technology TPU Roman black earth. It’s like they grow on the implant surface evenly, this is a kind of boundary between bone and titanium. Nanotubes just don’t allow the Titan to take more mechanical loading than bone. In addition, titanium is bioinert, it interacts weakly with biological structures and fluids. To better survive, its surface should be modified. To this end, we have developed nanotube products that «mask» the implant under the bone tissue. As a result, he catches on faster.»

Nanotubes are hollow cylinders made of titanium dioxide with a length from several tens of nanometers to about 8-10 micrometers. They can also be synthesized on the surfaces of other alloys. To the patient is not rejected alien implant, nanotubes do identical in composition to human bones, causing them coating of calcium phosphate or hydroxyapatite. Calcium and phosphorus, included in the calcium phosphate – based inorganic phase of bone tissue. Hydroxyapatite, also belonging to the class of calcium-phosphate is the primary mineral component of bones and teeth.

© Photo : Joel Brehm, University of Nebraska-Lincoln Office of Research and Economic DevelopmentТрехмерная visualization of carbon nanotubes of variable diameterRussian scientists had «grown» a bony shell on the titanium implants© Photo : Joel Brehm, University of Nebraska-Lincoln Office of Research and Economic DevelopmentТрехмерная visualization of carbon nanotubes AC demetropolise applied to nanotubes by RF magnetron sputtering. «Target», the Foundation for the growth of the coating, the ions bombard the inert gas, literally knocking the particles, which are deposited in a thin layer on the nanotube surface. Thanks to this the coatings have high adhesive strength, that is stronger than join the Titan.

Hollow inside nanotubes is ideal also in order to load them with drugs, delivering them to the desired area of the body together with the implant.

«Nanotubes allow you to control the speed of drug delivery to the patient, explains the scientific head of project, head of technology Center TPU Roman Surmenev. – If the cover of their amorphous calcium phosphate, to achieve dissolution of the drug in a period of weeks to months. If you need a prolonged effect, for example, to medication gradually came into the body in the course of the year, you can cover the nanotube hydroxyapatite, which is a structurally ordered items. In the future this technology will allow us to approach the treatment and rehabilitation of each patient personalized, selecting the type of nanotubes for implants, which is necessary in each specific case».

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