Scientists have uncovered the mechanism of occurrence of nicotine dependence

© RIA Novosti / Michael Voskresenskiye in fotobanka manufacturing cigarettesScientists have uncovered the mechanism of occurrence of nicotine dependence© RIA Novosti / Michael Voskresenskiye the image Bank

A group of scientists from China and the U.S. directed by INES Ibanez-Tallon from the Rockefeller University have found changes in brain cells that contribute to the development of nicotine addiction. The results of the study presented in the journal Proceedings of the National Academy of Sciences.

In the paper it notes that nicotine acts on brain receptors that secrete «hormones of joy», including dopamine. Researchers have attempted to identify cells responding to stimulation in the course of the experiment on mice for six weeks the rodents were fed with water containing nicotine. Emphasis was placed on two structures of the midbrain — sipusername the core and medial shell.

The experiment indicated lipozyme core: there have been found neurons whose functions have been changed under the influence of permanent use of nicotine. These cells scientists call Amigo1. According to researchers, they contribute to the development of dependence, breaking the connection between the two brain structures.

As a rule, the interaction of the medial shell and core sipusername leads to the development of low dose of «remuneration» and protects from the development of nicotine addiction. However, cells Amigo1 with constant exposure stimulator block this effect, explain the researchers.

Behavioral tests showed that mice addicted to nicotine. The researchers offered the rodents a choice to stay in the room where used to give water with nicotine or go. The majority of mice chose the first option in the calculation of the new dose.

Other experiments have confirmed that addiction to stimulant really depends on neuronal group Amigo1. When scientists «muted» these cells using genetic engineering, «bad habit» had disappeared.

Researchers believe that in the same way the nicotine reacts and the brain: the more one exposes himself to the effects of the stimulant, the more the brain produces substances that violate the protection mechanism. The authors note that the event is only a step towards a full understanding of the principles of influence of nicotine on the work of brain cells. In the end, the experts plan to come to the point of creating methods of anti-Smoking therapy.

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