Science with a hangover and how to sober up and sober

© Flickr / mislav-magoolScience with a hangover and how to sober up and sober© Flickr / mislav-marohnic

While drinking people don’t think about what awaits them the next morning. And for good reason. Unquenchable thirst, headache, General weakness — is the constant companion of a strong hangover. When it gets bad, it is better to consult a doctor, and a condition of average weight it is possible to try to neutralize at home. Unless, of course, to know how alcohol acts on the body.

When the morning worse in the evening

From the stomach into the blood is a small amount of alcohol consumed. Most of it is absorbed through the duodenal wall, dotted with a large number of blood vessels. With the blood of a molecule of ethanol (the active substance of any intoxicating drink) fall into the portal vein going to the liver. There is split a little bit of molecules, others continue to circulate through the circulatory system until it will pass through the liver, where it decomposes some number.

Wandering of alcohol in the blood continues until its concentration falls to a natural level. Yes, the human body always contains a certain background amount of ethanol, although very small — not more than one milligram per liter. Only the liver processes about 90% of the chest alcohol, the rest is excreted by the kidneys with the urine, the lungs during respiration and the skin through sweat.

Upon detection of ethanol in the liver involves three basic enzyme — alcohol dehydrogenase, cytochrome 2E1 and acetyldihydrocodeine. The first two oxidize ethanol with the formation of acetaldehyde, which is then converted by the third enzyme in the acetic acid, breaking up into water and carbon dioxide with the release of energy. From all the decay products of acetaldehyde poisoning the most. And the sooner he leaves the body, the sooner will improve the health of the person and the less damage will incur his organs. The fact that acetaldehyde is a chemically active molecule interacting with proteins and impairs their function. Under attack the Central nervous system and various tissues. This also caused General weakness, an unhealthy condition on the morning after the feast.

Ethanol splits the sooner, the more active the enzymes. The concentration of alcohol dehydrogenase depends on the sex, weight and age of the person, but to a greater extent on genetics. Unfortunately, artificially increase the activity of this enzyme impossible. However, the health of another enzyme of the cytochrome 2E1 — can be increased with the regular use of alcoholic beverages, so the «trained people» bounce back faster. And yet sobering in any case requires time, and therefore, prepare for the hangover it is possible and necessary in advance, even before he took the first dose.

How to help liver

Given that acetaldehyde is extremely aggressive, it is logical to associate it with some foreign substance. Come to the aid of the usual activated charcoal (normal to calculate just one tablet for 10 kg body weight). It is possible to drink before the holiday — this will greatly facilitate the morning condition. Will fit other sorbents, enterosgel for example, oatmeal, rice.

Since the main impact of the ethanol takes the liver, it will not be superfluous to unload it. Quite often, to drink clean water that spirits left the body together with urine. A warm shower will accelerate the excretion of ethanol and acetaldehyde through sweat. With the same task to cope with Jogging or active charging, unless, of course, be able to bring myself to do them. But those who have problems with the cardiovascular system, locomotor activity is better to abstain.

The acid slows down the formation of acetaldehyde and, therefore, will limit its accumulation in the body. Its a lot of citrus. It is better to take raw fruits because they have more useful components. Instead of trying to put the tea a slice of lemon, it is better to eat a whole orange or a grapefruit.

Science with a hangover and how to sober up and sober© RIA Novosti, Infographicsrussia Christmas table: what to submit and how to eat

One bite and can’t swallow with a hangover, and the other wakes up your appetite. Of course, drinking on an empty stomach is not necessary, because of the digestive system, the alcohol gets into your bloodstream quickly. Dense snack inhibits this process three or four times. Note, however, that the liver and so is actively working, trying to breakdown and excrete ethanol with acetaldehyde. It is not necessary to overload a large amount of food, especially fat. Appetite better to quench light soups, cereals, white fish, vegetables and other quickly digested foods. Since alcohol disrupts the sodium-potassium balance in the body is to consume potassium-rich items, such as bananas or potatoes.

«Perhaps it is surprising to hear from the doctor, but the hangover is the most reliable way sober. Otherwise you’ll have to wait until the processes described above will be completed for yourself. After 10-12 hours after a heavy libations you can enjoy 50-70 grams of strong alcohol, if they drank it or equivalent dose of some other drink. Since the activity of some enzymes and stimulates others, re-appointment activates the whole cascade of metabolic and toxic acetaldehyde will quickly oxidize to a safe molecules. The Board, however, fit regularly consume individuals, especially alcoholics — morning glass they naturally will lead to sing,» says Alex buyeverov, Professor, First Moscow state medical University named after I. M. Sechenov.
Heavy artillery

If General weakness and headache are not even after Breakfast, sorbents and soul, you should contact the medicines. Only do not take tablets containing paracetamol, Panadol, Advil and others. By itself, the molecule of paracetamol is harmless, this drug is give as ingesting even small children. He «peacefully» is associated with substances that increase its solubility in water, and excreted in the urine. But an excess of paracetamol starts the process of decomposition in the liver, resulting in the formation of extremely toxic substances. Alcohol is just stimulates the enzymes responsible for this metabolism. Better to take an aspirin, and effervescent work more quickly.