Scientists have developed an improved bone frame

© RIA Novosti / Ramil to Setdiscoverable in fotomonster with an artificial hipScientists have developed an improved bone frame© RIA Novosti / Ramil to Setdiscoverable the image Bank

Scientists from the University of Helsinki and the Institute of theoretical and experimental Biophysics of RAS have developed bone scaffolds for treatment of bone diseases. The results of their work are published in the journal International journal of Pharmaceutics.

Modern science is quite successfully progressing in the field of bone tissue engineering, to be able to replace the damaged bone. The point is to grow the living tissue outside the body, constructing it the way you want. The bone is then ready to transplant patients. This approach is justified when there is no opportunity to grow the body from the tissues of the patient or transfer him to someone else’s body. The problem is to find an artificial material is compatible with the human body and thus wear-resistant. To the solution of the problem approached the authors, using bone scaffolds hydroxyapatite, gelatin, polypyrrole and mesoporous silica. They added the structure of the antibiotic, using her as a vehicle for drug delivery to the diseased organ, and tested.

«Properties of the obtained materials were compared in different experiments. Cages containing polypyrrole, showed good mechanical properties and better absorbed protein. They also had a higher percentage of release of the model antibiotic, vancomycin, for a longer time compared to the other frames. Bone cells placed in the test materials remained viable for 14 days, suggesting their good biocompatibility,» commented the study one of the authors, senior researcher of the laboratory of tissue engineering ITEB RAS, candidate of biological Sciences Yuri Shatalin.

Each of the elements of a new type of skeletal frame has advantages and disadvantages, but taken together they showed the best properties. In particular, new material has accelerated the bone regeneration and time of the release of antibacterial substances lasted up to four months from the date of introduction.

© Photo : Yuri Shatalin/ITEB rasobratza the materials based on gelatin, mesoporous silica, hydroxyapatite and polypyrrole (+PP). The image of the surface of the material obtained by scanning electron microscopy (SEM).Scientists have developed an improved bone frame© Photo : Yuri Shatalin/ITEB rasobratza the materials based on gelatin, mesoporous silica, hydroxyapatite and polypyrrole (+PP). The image of the surface of the material obtained by scanning electron microscopy (SEM).

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