To evaluate a new method of cancer control is possible in 5-10 years, says expert

© RIA Novosti / Sergey Patkovskiy Kadagidze: immunotherapy – could become a revolution in OncologyTo evaluate a new method of cancer control is possible in 5-10 years, says expert© RIA Novosti / Sergey Petaloudes to daily updates RIA Science

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To evaluate the effectiveness of new techniques that made the cancer cells to destroy the tumor, it will be possible not earlier than in 5-10 years, said RIA Novosti head of the Department of development and external relations, researcher, fsbi «Sri of Oncology. N. N. Petrov» Yury Komarov.

Scientists from Harvard medical school in the United States have developed two methods of combating tumors with genetically modified cancer cells circulating in the bloodstream. Their study published in the journal Science Translational Medicine.

«This study was conducted in vitro and were carried out on a number of mice with certain types of tumors. This type of research in the preclinical phase quite a lot, it’s like one of the new methods that show the effect on a small sample of mice, but the clinic is not the fact that will work,» — said the expert.

«If we talk about how it can enter into practice, it is actually quite a long process. Should conduct in-depth preclinical studies on various animals with various tumors and after confirming the safety of the method in the first phase, you can move on to the second and third phase of clinical trials, where it will be possible to evaluate the effectiveness of this method in relation to a person,» — said the Agency interlocutor.

He said that on average, «such studies show its effectiveness not earlier than in 5-10 years.» The expert also said that Russia has conducted many similar studies, including the stage of clinical trials.

Circulating tumor cells separate from the original produced in the body tumors and enter the bloodstream, but in the future can return to the tumor. They are responsible for the appearance of metastases — distant secondary foci of disease.

As a means against tumors, the researchers used the so-called protein-assassin’S-TRAIL, which proved to be the least harmful to healthy cells of the body. This protein is able to trigger apoptosis — programmed cell death.

In their study, American doctors have tried two approaches to therapy circulating cells. In the first case, they used glioblastoma cells — an aggressive brain tumors are initially resistant to S-TRAIL. However, subjecting them to genetic modification, scientists have been able to get them to actively produce protein-the killer and then injected these cells experimental mice with primary tumors.

The second method used for rodents with re-occurring tumors. Of tissue primary tumors scientists obtained cells sensitive to S-TRAIL, and with the help of genetic engineering was first off the receptors responsible for this susceptibility to cell not killed himself prematurely. Then the prepared cells are forced to produce S-TRAIL and introduced their animals. In both types of cells embedded «switch» that triggers the process of self-destruction of cells-killers after treatment.

According to scientists, both of the tested method was effective. The tests also included mice with primary and secondary brain tumors and breast cancer. As a result, physicians were able to reduce the size of the tumors all types, a mouse that had received such treatment were able to live longer.

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