Doctors have created a «universal» nanovaccines against influenza

© Depositphotos / Syda_ProductionsБабушка with handkerchiefDoctors have created a «universal» nanovaccines against influenza© Depositphotos / Syda_ProductionsПодпишись to daily updates RIA Science

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American molecular biologists have created nanovaccines protect from rare and common strains of influenza, and has successfully tested it on mice. Their findings were published in the journal PNAS.

«Our new vaccine acts on T-cells responsible for the cellular response to infection, and b-cells to produce antibodies. In addition, its effectiveness has improved due to the use of the patch with a set of microneedles. All this opens the way to create a cheap universal flu vaccine,» says Bao-Zhong Wang (Bao-Zhong Wang) from Georgia state University in Atlanta (USA).

Each year, influenza epidemics claim the lives of many thousands of patients. The fight against the flu is complicated by the fact that there are three varieties of this virus – A, b and C, which makes quite difficult to predict what kind of virus will be prevailing next year. In addition, vaccination allows the immune system to develop one or more strains of influenza virus.

The most dangerous flu viruses of the type A. Varieties of this virus are divided into groups A1 and A2 depending on the composition of the protein shell of the virus, defining the mechanism of infection of the cells of a host organism. The first group is «swine» flu, the second – the virus avian influenza.

Viruses within each group are quite different in structure, and organism, and the vaccine manufacturers have to adapt to new strains of flu every year. Thanks to these vaccines and the fact that people develop immunity to the current «version» of the virus in nature there was a kind of «circulation» of strains of influenza, alternately circulate among people, birds and animals, forcing scientists each year to create new flu shots.

At the beginning of this year, Wang and his colleagues created the first prototype of a universal nanovaccine that protects humans and animals from infection by almost all strains of influenza virus type A, which are associated with all of the most serious epidemics in history.

A successful test of this prototype has led scientists to think about whether you can force her to deal with all types and subtypes of influenza virus, and to reinforce its action. Following this idea, scientists have changed the structure of nanoparticles, replacing them with fatty components to other protein components of the virus, including its «foot» with which it clings to the spines on the surface of lung cells of people and animals.

The new version of the vaccine, as demonstrated by experiments on mice, protected rodents from lethal doses of multiple strains of influenza, as belonging to the epidemic versions of the virus, and to more rare varieties.

Subsequent experiments and add other elements of the virus in these nanoparticles, according to Wang, will create a truly universal flu vaccine capable of protecting humans from all varieties of this disease, not only a rare and contagious virus type A.

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